GWAS of ECT-based predicted TRD
This is a repository of all scripts used for genetic analyses of our publication, which include:
- meta-analysis using METAL and PLINK
- GWAS results plotting: QQ, Manhattan, Forest plots
- LDSC SNP heritability estimation and genetic correlation
- Polygenic risk score (PRS) association with leave-one-out summary statistics
Prerequisite software: METAL and plink for meta-analysis, PRSCS for polygenic risk scores
Check out the Wiki for detailed steps. Meta-analysis summary statistics are available here for download.
Citation: https://doi.org/10.1101/2022.08.10.22278630
Please contact douglas.ruderfer@vumc.org if you have any questions.