diff --git a/setup.py b/setup.py
index 120afcee..8b1e0260 100644
--- a/setup.py
+++ b/setup.py
@@ -24,7 +24,7 @@
     "setuptools",
     "db-dtypes >=1.0.4,<2.0.0",
     "numpy >=1.18.1",
-    "pandas >=1.1.4, <3.0.0",
+    "pandas >=1.1.4",
     "pyarrow >=4.0.0",
     "pydata-google-auth >=1.5.0",
     "psutil >=5.9.8",
diff --git a/tests/system/test_to_gbq.py b/tests/system/test_to_gbq.py
index ad7c58ec..d6a3577e 100644
--- a/tests/system/test_to_gbq.py
+++ b/tests/system/test_to_gbq.py
@@ -155,7 +155,7 @@ def test_series_round_trip(
                         dtype="boolean",
                     ),
                     "object_col": pandas.Series(
-                        [False, None, True],
+                        [False, pandas.NA, True],
                         dtype="object",
                     ),
                 }
@@ -344,7 +344,10 @@ def test_series_round_trip(
                     # google-cloud-bigquery versions 1.x and 2.x, but not 3.x.
                     # https://github.com/googleapis/python-bigquery-pandas/issues/365
                     "datetime_col": [
-                        datetime.datetime(1, 1, 1),
+                        # CSV loader in BigQuery currently requires leading 0s
+                        # for TIMESTAMP but not DATETIME. See internal issue
+                        # b/467399807.
+                        datetime.datetime(1000, 1, 1),
                         datetime.datetime(1970, 1, 1),
                         datetime.datetime(9999, 12, 31, 23, 59, 59, 999999),
                     ],