diff --git a/requirements.txt b/requirements.txt
index 76f0fc7..a2a4d4c 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -1,6 +1,6 @@
 requests==2.32.2
 python-dateutil==2.8.2
-cryptography==44.0.3
+cryptography==45.0.6
 six==1.16.0
 ruamel.yaml==0.18.5
 pynacl==1.5.0
diff --git a/setup.py b/setup.py
index 40dd94d..1ddb264 100644
--- a/setup.py
+++ b/setup.py
@@ -15,7 +15,7 @@
       url="https://github.com/Venafi/vcert-python",
       packages=['vcert', 'vcert.parser', 'vcert.policy'],
       install_requires=['requests==2.31.0', 'python-dateutil==2.8.2', 'six==1.16.0',
-                        'cryptography==44.0.3', 'ruamel.yaml==0.18.5', 'pynacl==1.5.0'],
+                        'cryptography==45.0.6', 'ruamel.yaml==0.18.5', 'pynacl==1.5.0'],
       description='Python client library for Venafi Trust Protection Platform and Venafi Cloud.',
       long_description=long_description,
       long_description_content_type="text/markdown",