diff --git a/GPU/GPUTracking/Definitions/GPUSettingsList.h b/GPU/GPUTracking/Definitions/GPUSettingsList.h
index f7ff14ea188c4..d8173a5b62a35 100644
--- a/GPU/GPUTracking/Definitions/GPUSettingsList.h
+++ b/GPU/GPUTracking/Definitions/GPUSettingsList.h
@@ -370,6 +370,7 @@ AddOption(debugOnFailureMaxN, uint32_t, 1, "", 0, "Max number of times to run th
 AddOption(debugOnFailureMaxFiles, uint32_t, 0, "", 0, "Max number of files to have in the target folder")
 AddOption(debugOnFailureMaxSize, uint32_t, 0, "", 0, "Max size of existing dumps in the target folder in GB")
 AddOption(debugOnFailureDirectory, std::string, ".", "", 0, "Target folder for debug / dump")
+AddOption(amdMI100SerializationWorkaround, bool, false, "", 0, "Enable workaround that mitigates MI100 serialization bug")
 AddVariable(eventDisplay, o2::gpu::GPUDisplayFrontendInterface*, nullptr)
 AddSubConfig(GPUSettingsProcessingRTC, rtc)
 AddSubConfig(GPUSettingsProcessingRTCtechnical, rtctech)
diff --git a/GPU/GPUTracking/Global/GPUChainTrackingSectorTracker.cxx b/GPU/GPUTracking/Global/GPUChainTrackingSectorTracker.cxx
index 67ef402961a20..708037239071e 100644
--- a/GPU/GPUTracking/Global/GPUChainTrackingSectorTracker.cxx
+++ b/GPU/GPUTracking/Global/GPUChainTrackingSectorTracker.cxx
@@ -161,6 +161,9 @@ int32_t GPUChainTracking::RunTPCTrackingSectors_internal()
     GPUTPCTracker& trk = processors()->tpcTrackers[iSector];
     GPUTPCTracker& trkShadow = doGPU ? processorsShadow()->tpcTrackers[iSector] : trk;
     int32_t useStream = StreamForSector(iSector);
+    if (GetProcessingSettings().amdMI100SerializationWorkaround) {
+      SynchronizeStream(useStream); // TODO: Remove this workaround once fixed on MI100
+    }
 
     if (GetProcessingSettings().debugLevel >= 3) {
       GPUInfo("Creating Sector Data (Sector %d)", iSector);